SystemsEnergetics

Funders

The Great Britain SASAKAWA FOUNDATION
BBSRC, Innovate UK, Great Brit

Date

Aug 30th, 2023
9:30 ~ 11:50

Moderator

Noriko F. Hiroi will present a short opening remarks;
"Life knows everything: interdiciplinary scientific researches open the holison of new circuration era".

Speakers

Prof. Viji M. Draviam (Queen Mary University of London, UK)
Dr. Jie Lin (Genentech Inc., USA)
Prof. Nishanth R. Sastry (University of Surrey, UK)
Dr. Isabel Palacios (Queen Mary University of London/University of Cambridge, UK)

Program

The detail will be coming soon!

Brief heighlights

The session we organise is an interdisciplinary session, which consists of the topics in life science relating expanded their outcome with the other area’s technologies such as electronics, pharmaceutics, informatics, and pedagogy. Through these topics, all the speakers will play an essential part to configure our vision.

Prof. Viji M. Draviam

Prof. Viji M. Draviam has contributed for a long time to the research of cell proliferation mechanisms including chromatin segregation and spindle orientation. She uses imageing technologies, such as high-speed imaging with electrically focus tunable lens, and automation of focusing and aquiring images to produce large-scale, quantitative data, which are suitable for up-to-date bioinformatical analyses. Such her research style is widely recognised by microscopy companies, now Carl Zeiss, which is the one of the top companies of microscope supports her and her studetns research.
[Ref]
1. Song X, Conti D, Shrestha RL, Braun D, Draviam VM. Counteraction between Astrin-PP1 and Cyclin-B-CDK1 pathways protects chromosome-microtubule attachments independent of biorientation. Nat Commun. 2021 Dec 1;12(1):7010. doi: 10.1038/s41467-021-27131-9. PMID: 34853300; PMCID: PMC8636589.
2. Hart, M., Adams, S.D. & Draviam, V.M. Multinucleation associated DNA damage blocks proliferation in p53-compromised cells. Commun Biol 4, 451 (2021). https://doi.org/10.1038/s42003-021-01979-5
3. Conti D, Gul P, Islam A, Martín-Durán JM, Pickersgill RW, Draviam VM. Kinetochores attached to microtubule-ends are stabilised by Astrin bound PP1 to ensure proper chromosome segregation. Elife. 2019 Dec 6;8:e49325. doi: 10.7554/eLife.49325. PMID: 31808746; PMCID: PMC6930079.

Dr. Jie Lin

Dr. Jie Lin earned her PhD at the University of Tokyo, Department of Molecular Biology and Biochemistry, Graduate school of medicine. After she graduated the University of Tokyo, she started to work in the Department of Molecular Oncology, Genentech Inc., South San Francisco, CA, USA. She will give a presentation about a complicated resistance pathways against AKT inhibitors based on the nature communications paper published on 2022 and the background works.
[Ref]
1. Savill, K.M.Z., Lee, B.B., Oeh, J., Lin, J. et al. Distinct resistance mechanisms arise to allosteric vs. ATP-competitive AKT inhibitors. Nat Commun 13, 2057 (2022). https://doi.org/10.1038/s41467-022-29655-0
2. Lin, J., Sampath, D., Nannini, M. A., Lee, B. B., Degtyarev, M., Oeh, J., Savage, H., Guan, Z., Hong, R., Kassees, R., Lee, L. B., Risom, T., Gross, S., Liederer, B. M., Koeppen, H., Skelton, N. J., Wallin, J. J., Belvin, M., Punnoose, E., … Lin, K. (2013). Targeting Activated Akt with GDC-0068, a Novel Selective Akt Inhibitor That Is Efficacious in Multiple Tumor Models. Clinical Cancer Research, 19(7), 1760–1772. https://doi.org/10.1158/1078-0432.ccr-12-3072
3. Lin K, Lin J, Wu WI, Ballard J, Lee BB, Gloor SL, Vigers GP, Morales TH, Friedman LS, Skelton N, Brandhuber BJ. An ATP-site on-off switch that restricts phosphatase accessibility of Akt. Sci Signal. 2012 May 8;5(223):ra37. doi: 10.1126/scisignal.2002618. PMID: 22569334.

Prof. Nishanth R. Sastry

The research subjects of Prof. Sastry are the one of the most fascinating and significant for the current world situation which people naturally are involved into the communication networks via internet. The researches he has accomplished may give a distinct insight and strategies how we can watch up and maintain our personal information security. He developped applications of his original algorithm in his research field, graph neural learning technique, which works cooperating manner with the other machine learning and data analysis approaches. The opportunity to listen his talk and discuss with a key-person of such innovative research would be of great interest to the researchers and students at the Kanagawa Institute of Technology.
[Ref]
1. Gioia Boschi, Peter Young, Sagar Joglekar, Chiara Cammarota, Nishanth Sastry (2021). Who has the last word? Understanding How to Sample Online Discussions. ACM Transactions on the Web (TWEB).
2. Jiaqiang Liu, Huan Yan, Yong Li, Dmytro Karamshuk, Nishanth Sastry, Di Wu, Depeng Jin (2021). Discovering and Understanding Geographical Video Viewing Patterns in Urban Neighborhoods. IEEE Transactions on Big Data.
3. Ranjan Pal, Ziyuan Huang, Xinlong Yin, Sergey Lototsky, Swades De, Sasu Tarkoma, Mingyan Liu, Jon Crowcroft, Nishanth Sastry (2021). Aggregate Cyber-Risk Management in the IoT Age Cautionary Statistics for (Re)Insurers and Likes. IEEE Internet of Things Journal.

Dr. Isabel Palacios

Dr. Isabel Palacios is a strong researcher of development mechanisms of fruit fly especially the biophysical role of cytosletal proteins. She is not just working for her scientific interest, but also contribute for the education of African children. She and her folks built an organization named DrosAfrica which expand the opportunities for African children to learn life science using fruit fly.
[Ref]
1. Vicente-Crespo M, Martín-Bermudo MD, and Palacios IM (2020). The humble fruit fly is helping the African science community to thrive. Nature Reviews MCB doi.10.1038/s41580-020-00283-0
2. Drechsler M, Lang LF, Al-Khatib L, Dirks H, Burger M, Schönlieb CB, Palacios IM (2020). Optical flow analysis reveals that Kinesin-mediated advection impacts on the orientation of microtubules. Mol Biol Cell. Jun 1;31(12):1246-1258. doi: 10.1091/mbc.E19-08-0440.
3. Drechsler M, Giavazzi F, Cerbino R and Palacios IM. (2017). Active diffusion and advection in the Drosophila ooplasm are due to the interplay of the microtubule and actin cytoskeletons. Nature Communications, DOI : 10.1038/s41467-017-01414-6.